The MARCH family of RING-finger E3 ubiquitin ligases comprise 11 members that have been reported to play a variety of roles in the downregulation of cell-surface proteins involved in adaptive immunity.The RING-CH domain of MARCH proteins is thought to ubiquitinate the cytoplasmic tails (CTs) of target proteins, leading to protein degradation throug
We may soon face biophysical limits to perpetual growth.Energy supplies may tighten and then begin a long slow descent while defensive expenditures rise to address problems caused by past resource consumption.The outcome may be significant changes in daily routines at the individual and community level.It is difficult to know when this scenario mig
S-adenosylmethionine (SAM) is an important compound in living organisms and has a number of different roles, such as polyamine synthesis.It can also be used for the treatment of diseases.Gene targeting with homologous recombination in Komagataella phaffii (K.phaffii) created DAS1 and DAS2 gene knockout strains, which use the methanol pathway to gen